Ekaterina Korobkova
Ekaterina
Korobkova
Associate Professor
Phone number
212.237.8064
Room number
05.66.26NB

Areas of expertise

Faculty Expertise: topics/keywords

Biochemistry, Biophysics, Physical Chemistry

In the media

Print/Online

Malaysha Rice, Bokey Wong, Mare Oja, Kelley Samuels, Alicia K. Williams, Jenny Fong, Anne-Marie Sapse, Uko Maran, and Ekaterina A. Korobkova, Bioorg. Med. Chem., “A role of flavonoids in cytochrome c-cardiolipin interactions”, 2021, 33, 116043.

Ekaterina A. Korobkova, Chem. Res. Toxicol., “Effect of Natural Polyphenols on CYP Metabolism: Implications for Diseases”, 2015, 28 (7), 1359-1390. (Chosen for the cover of the issue)

Ekaterina A. Korobkova, Pharm. Anal. Acta, “Dynamics of HSP60-CypD Binding Studied with Surface Plasmon Resonance”, 2015, 6 (10), 432.

Ekaterina A. Korobkova, Book Chapter: “Interactions of Natural Polyphenols with Phospholipids: Implication in Oxidative Stress and Neurodegenerative Diseases” in Jason Hernandez (Ed.): “Lecithins and Phospholipids: Biochemistry, Properties and Clinical Significance”, 2015. Hauppauge, NY 11788: Nova Science Publishers, Inc.

Ekaterina A. Korobkova, Book Chapter: “Phospholipids and peroxidases in mitochondrial apoptosis” in Lucas Bogaert and Noah Coppens (Ed.): “Peroxidases: Biochemical Characteristics, Functions and Potential Applications”, 2013 (pp. 75-100 - (NBC-C)). Hauppauge, NY 11788: Nova Science Publishers, Inc.

Alicia K. Williams, Sofia Cheliout Dasilva, Melinda Liu, Baibhav Rawal, Ankit Bhatta, and Ekaterina A. Korobkova, Anal. Biochem., “Determination of the drug-DNA binding modes using fluorescence-based assays”, 2012, 422, 66-73.

Ekaterina A. Korobkova, John Nemeth, Mikeisha Cadougan, Abhishek Venkatratnam, Mohanram Bassit, and Nikolay Azar, Bioorg. Med. Chem., “Reactive metabolites of desipramine and clomipramine: The kinetics of formation and reactivity with DNA”, 2012, 20 (1), 340-345.

Ekaterina A. Korobkova, William Ng, Abhishek Venkatratnam, Alicia K. Williams, Madina Nizamova, and Nikolay Azar, Chem. Res. Toxicol,. “In-vitro studies of DNA damage caused by tricyclic antidepressants: a role of peroxidase in side effects of the drugs”, 2010, 23, 1497-1503.

Jason Chen, Ekaterina Korobkova, Heng Zhu, and Chuan He, Nat. Methods, “A proteome chip approach reveals new DNA damage recognition activities in Escherichia coli”, 2008, 5 (1), 69-74.

Ekaterina A. Korobkova, Thierry Emonet, Heungwon Park, and Philippe Cluzel, Phys. Rev. Lett., “Hidden stochastic nature of a single bacterial motor”, 2006, 96, 058105-1 – 058105-4.

Ekaterina Korobkova, Thierry Emonet, Jose M. G. Vilar, Thomas S. Shimizu, Philippe Cluzel, Nature, “From molecular noise to behavioral variability in a single bacterium”, 2004, 428 (6982), 574-578.

Download CV

Education

2004   PhD       -    The University of Chicago (Biophysical Chemistry)
2001   MS         -    Boston University (Physical Chemistry)
1999  Diploma  -    Novosibirsk State University, Russia (Chemistry)

Bio

 

 

Research Summary

My research interests center on flavonoids, secondary products of plant metabolism. These compounds significantly affect human health as they are present in everyday foods such as tea, juices, fruits, vegetables and other plant products. Recently, our research efforts focused on (1) the interactions of flavonoids with cytochrome c, a protein located on the inner mitochondrial membrane that plays a significant role in oxidative phosphorylation and apoptosis; (2) interactions of flavonoids and specifically anthocyanins with metal cations. These interactions play an important role in the metabolism of polyphenolic compounds and metal homeostasis in the human body. The metal chelate complexes of anthocyanins affect plant colors and modulate various physiological and ecological processes.

Research interests: flavonoids, metal-anthocyanin complexes, mitochondrial proteins, peroxidases, cytochrome c.